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Volume Two of Our Invivo Preclinical Questions Answered Series

Also see Volumes One and Three

Can a dental cement headcap be removed with acetone?

It is possible to dissolve dental cement with acetone, although it may damage materials used to make cannulas and electrodes. While P1 Technologies does not condone reusing components after the initial surgery, we understand that some researchers choose to do so. Any components recovered from animals should be thoroughly inspected for damage. P1 Technologies guarantees all components from defects for one time use.

What is the smallest diameter electrode you produce? What if I want something else?

We carry a variety of wire sizes for our electrode lines. In stainless steel, our smallest wire diameter is 0.005”. In platinum, our smallest wire diameter is 0.003”. If you need a different size or wire material, please give us a call. We can supply many other types of wire or you can supply your own material to us. The P1 Technologies electrode line is customizable to suit your requirements.

Do you sell fiber optic patch cables?

While we do carry components for working with fiber optics in animals, we do not carry the cables themselves or the swivels. We recommend you contact Doric Lenses or Thor Labs for these needs.

Do you have MRI compatible components?

We are proud to offer a selection of components made entirely of MRI compatible materials. We currently have single guide systems, osmotic pump connectors and backmounts made with PEEK, Teflon or fused silica glass. We also carry a line of MRI compatible electrodes to fit your needs. If what you need is not immediately available, we will be glad to work with you to find a solution that works for you.

What cannula should I use for ICV injection into the lateral ventricle?

It depends on the parameters of your study. For instance, a mouse is fairly small, so we would recommend a smaller gauge cannula system than for someone using a rat. To determine which components will work best for you, we’ recommend that you consider these factors:

  • Animal
  • Duration of Study
  • Area of Study
  • Substance for Injection
When choosing a cannula system, the researcher should consider all of these factors and choose the system that creates the smallest damage profile while allowing for adequate substance flow. Headcap size should also be considered, as larger cannulas can create weight issues on the animal or space issues inside the home cage.

For specific information or help with your design, please give us a call.

By: Aubrey Shifflett